Laurens Manning Selected Research

Penicillin G (Benzylpenicillin)

1/2022	Penicillin G concentrations required for prophylaxis against Group A Streptococcus infection evaluated using a hollow fibre model and mathematical modelling.
10/2021	Revisiting the inoculum effect for Streptococcus pyogenes with a hollow fibre infection model.
1/2019	A population pharmacokinetic study of benzathine benzylpenicillin G administration in children and adolescents with rheumatic heart disease: new insights for improved secondary prophylaxis strategies.
1/2017	Penicillin Dried Blood Spot Assay for Use in Patients Receiving Intramuscular Benzathine Penicillin G and Other Penicillin Preparations To Prevent Rheumatic Fever.

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Laurens Manning Research Topics

Disease

25	Infections 07/2022 - 04/2010
13	Malaria 01/2019 - 06/2007
6	Rheumatic Heart Disease (Rheumatic Heart Diseases) 01/2022 - 01/2019
5	Rheumatic Fever (Acute Articular Rheumatism) 01/2022 - 01/2017
4	Vivax Malaria 04/2022 - 01/2012
4	Falciparum Malaria (Plasmodium falciparum Malaria) 01/2017 - 11/2011
3	COVID-19 06/2022 - 07/2021
3	Anemia 10/2018 - 04/2010
3	Bacterial Meningitis 10/2018 - 09/2011
2	Wounds and Injuries (Trauma) 03/2022 - 04/2018
2	Foot Diseases 07/2021 - 04/2021
2	Critical Illness (Critically Ill) 03/2021 - 01/2020
2	Coma (Comas) 01/2019 - 02/2011
2	Bacterial Infections (Bacterial Infection) 10/2018 - 03/2012
2	Parasitemia 12/2014 - 02/2011
1	Overweight 06/2022
1	Type 2 Diabetes Mellitus (MODY) 06/2022
1	Staphylococcal Infections 03/2022
1	Lymphadenopathy 01/2022
1	Abscess 01/2022
1	Sickle Cell Trait 01/2022
1	Sickle Cell Anemia (Hemoglobin S Disease) 01/2022
1	Human Influenza (Influenza) 01/2022
1	Diabetes Mellitus 04/2021
1	Cross Infection (Nosocomial Infection) 03/2021
1	Syphilis 12/2020
1	Pain (Aches) 10/2020
1	Hemorrhage 07/2020
1	Frailty 01/2020
1	Anaphylaxis (Anaphylactic Shock) 06/2019
1	Liver Diseases (Liver Disease) 06/2019
1	Peripheral Vascular Diseases (Peripheral Vascular Disease) 04/2019
1	Foot Ulcer 01/2019
1	Diabetic Foot 01/2019
1	Sepsis (Septicemia) 01/2019
1	Necrotizing Enterocolitis 01/2019
1	Malnutrition (Nutritional Deficiencies) 01/2019
1	Hyperlactatemia 01/2019
1	Pneumonia (Pneumonitis) 10/2018
1	Melioidosis 04/2018
1	Glucosephosphate Dehydrogenase Deficiency 01/2017
1	Hip Fractures (Intertrochanteric Fractures) 01/2015

Drug/Important Bio-Agent (IBA)

7	Penicillin G Benzathine (Benzathine Benzylpenicillin)FDA Link 01/2022 - 01/2017
6	Anti-Bacterial Agents (Antibiotics)IBA 07/2022 - 03/2012
5	Antimalarials (Antimalarial Agents)IBA 04/2022 - 04/2010
5	artemisinin (artemisinine)IBA 01/2022 - 06/2007
4	Penicillin G (Benzylpenicillin)FDA LinkGeneric 01/2022 - 01/2017
3	Penicillins (Penicillin)FDA Link 01/2021 - 01/2017
3	Proteins (Proteins, Gene)FDA Link 12/2014 - 04/2010
3	AntigensIBA 06/2013 - 01/2012
3	Hemoglobins (Hemoglobin)IBA 01/2012 - 04/2010
2	Lumefantrine Drug Combination Artemether (Coartem)FDA Link 01/2022 - 12/2014
2	Ertapenem (Invanz)FDA Link 10/2021 - 04/2019
2	diformyl dapsone (DFD)IBA 07/2021 - 04/2021
2	Ceftriaxone (Ceftriaxon)FDA LinkGeneric 01/2020 - 10/2018
2	Lactic Acid (Lactate)FDA LinkGeneric 01/2019 - 02/2011
2	AntibodiesIBA 01/2019 - 01/2019
2	Immunoglobulin G (IgG)IBA 01/2019 - 01/2011
2	naphthoquineIBA 05/2016 - 12/2014
2	Chloroquine (Aralen)FDA LinkGeneric 01/2012 - 04/2010
2	Artemether FDA Link 11/2011 - 06/2007
1	Testosterone (Sustanon)FDA Link 06/2022
1	Rifampin (Rifampicin)FDA LinkGeneric 03/2022
1	Interferon-gamma (Interferon, gamma)IBA 01/2022
1	VaccinesIBA 01/2022
1	Influenza Vaccines (Influenza Vaccine)FDA Link 01/2022
1	Clindamycin (Cleocin)FDA LinkGeneric 10/2021
1	AnticoagulantsIBA 07/2020
1	Cystatin CIBA 01/2020
1	LactamsIBA 06/2019
1	Methicillin (Metin)FDA Link 06/2019
1	Cefazolin (Ancef)FDA LinkGeneric 06/2019
1	LincosamidesIBA 06/2019
1	Floxacillin (Flucloxacillin)IBA 06/2019
1	Tazobactam Drug Combination Piperacillin (Zosyn)FDA LinkGeneric 06/2019
1	Blood Glucose (Blood Sugar)IBA 01/2019
1	Surface Antigens (Surface Antigen)IBA 01/2019
1	Pentoxifylline (Trental)FDA LinkGeneric 01/2019
1	Serum AlbuminIBA 01/2019
1	Endothelial Protein C ReceptorIBA 01/2019
1	Plasmodium falciparum erythrocyte membrane protein 1IBA 01/2019
1	Saline SolutionIBA 04/2018
1	Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA 01/2017
1	EnzymesIBA 01/2017
1	Pharmaceutical PreparationsIBA 01/2016
1	Durapatite (Hydroxylapatite)IBA 01/2015
1	C-Reactive ProteinIBA 01/2015

Therapy/Procedure

11	Therapeutics 04/2022 - 04/2014
4	Replacement Arthroplasty 07/2022 - 01/2020
3	Prostheses and Implants (Prosthesis) 03/2022 - 01/2016
3	Injections 01/2022 - 10/2020
2	Debridement 07/2022 - 03/2022
2	Braces 01/2022 - 10/2021
2	Arthroplasty 01/2021 - 01/2020
2	Intramuscular Injections 10/2020 - 07/2020
1	Skin Transplantation (Skin Grafting) 03/2022
1	Surgical Amputation (Amputations) 03/2022
1	Secondary Prevention 10/2020
1	Immunomodulation 01/2019
1	Mass Drug Administration 12/2018